原创力文档Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression》.pdf
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Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression》.pdf
Chinese
Journal of
Natural
Chinese Journal of Natural Medicines 2015, 13(9): 06670672 Medicines
Quercetin promotes neurite growth through enhancing
intracellular cAMP level and GAP-43 expression
1 2 1* 1*
CHEN Ming-Ming , YIN Zhi-Qi , ZHANG Lu-Yong , LIAO Hong
1National Center for Drug Screening, China Pharmaceutical University, Nanjing 210009, China;
2Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China
Available online 20 Sep., 2015
[ABSTRACT] The present study was designed to investigate the role of quercetin on neurite growth in N1E-115 cells and the
underlying mechanisms. Quercetin was evaluated for its effects on cell numbers of neurites, neurite length, intracellular cAMP content,
and Gap-43 expression in N1E-115 cells in vitro by use of microscopy, LANCE™ cAMP 384 kit, and Western blot analysis,
respectively. Our results showed that quercetin could increase the neurite length in a concentration-dependent manner, but had no effect
on the numbers of cells. Quercetin significantly increased the expression of cellular cAMP in a time- and concentration-dependent
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