Radiation dosimetry estimates of 18F-alfatide II based on whole-body PET imaging of mice》.pdf

Applied Radiation and Isotopes 105 (2015) 1 –5 Contents lists available at ScienceDirect Applied Radiation and Isotopes journal homepage: /locate/apradiso Radiochemistry and radionuclide applications - A Radiation dosimetry estimates of 18F-alfatide II based on whole-body PET imaging of mice Si-yang Wang a,b,c,d, Xiao Bao a,b,c,d, Ming-wei Wang a,b,c,d, Yong-ping Zhang a,b,c,d, Ying-jian Zhang a,b,c,d, Jian-ping Zhang a,b,c,d,n a Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China b Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China c Center for Biomedical Imaging, Fudan University, Shanghai, China d Shanghai Engineering Research Center for Molecular Imaging Probes, Shanghai, China H I G H L I G H T S G R A P H I C A L A B S T R A C T We demonstrated a proper mice model to estimate human radiation dosimetry. This is the first paper to estimate human radiation dosimetry of 18F-alfatide II. Estimated effective dose are in the range of routine nuclear medicine studies. a r t i c l e i n f o a b s t r a c t Article history: We estimated the dosimetry of 18F-alfatide II with the method established by MIRD based on biodis- Received 16 December 2014 tribution data of mice. Six mice (three females and three males) were scanned for 160 min on an Inveon Received in revised form MicroPET/CT scanner after injection of 18F-alfatide II via tail vein. Eight source organs were deline