Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties》.pdf

European Journal of Medicinal Chemistry 102 (2015) 552e573 Contents lists available at ScienceDirect European Journal of Medicinal Chemistry journal homepage: http://www.elsevier .com/locate/ejmech Review article Recent developments regarding the use of thieno[2,3-d]pyrimidin-4- one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties a, b, 1 a b c Khurshed Bozorov , Jiang-Yu Zhao , Burkhon Elmuradov , Apar Pataer , Haji A. Aisa a, * a Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, South Beijing Road 40-1, Urumqi, Xinjiang 830011, PR China b Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, 77, Mirzo Ulugbek Str., 100170 Tashkent, Uzbekistan c Departments of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA a r t i c l e i n f o a b s t r a c t Article history: It is generally understood that the antitumor properties of synthetic heterocyclic compounds are among Received 12 June 2015 the most powerful properties that can be made use in medicinal chemistry. More specifically, their Received in revised form substantial cytotoxic effects against different types of human tumor cells, in addition to their roles as 4 August 2