《Efficacy of Jian＇ganle （健肝乐） versus Hugan Pian （护肝片）, Glucuronolactone and Reduced Glutathione in Prevention of Antituberculosis Drug-induced Liver Injury.》.pdf

JHuazhongUnivSciTechnolM『edSci] 450 DoI1olo07／sl1596．014-1299-； ()：。 ，。 Effi cacyofJian’ganle(健肝乐)versusHuganPian(护肝片)， Glucur0n0lact0neandReducedGlutathioneinPreventionof AntituberculosisDrug．inducedLiverInjury QuanZHANG(张 权)，Fang—yingZHONG(钟方莹)，Mengwu (吴 梦)，Xin—pingZHANG(张新平) SchoolofMedicineandHealthManagement,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan 430030,China ◎HuazhongUniversityofScienceandTechnologyandSpringer-VerlagBerlinHeidelberg2014 Summary：Evidence—basedmedicineisadvocatedbyW HO andadoptedby developedcountriesfor manyyears．InChina，however theselectionofessentialmedicineandvariousmedicalinsurancere． imbursementschemesmedicineisusuallybasedonexperts’experienceofprescriptionpracticewhichis underheavycriticsresultingfrom thelackofrelatedcomparativeefficacyandevidence．basedresearch． TheefficacyofJian’ganleinpreventionofdrug—inducedliverinjuryfDILI1causedbyantituberculotics wasevaluatedinthisstudybycomparisonwithHuganPian．glucuronolactoneandreducedglutathione． EvidencewasprovidedofrrelevantsectorssuchasMinistryofrHumanResourcesandSocialSecurity ofthePeople’sRepublicofChinaandNationa1HealthandFamily PlanningCommissionofthePeo． ple’sRepublicofChinatoselectandrenew theEssentia1MedicineListfEML1，thenewruralcoopera— tivemedicalschemeinChina(NRCMS)Iistorthereimbursementlistofindustria¨niuryinsurance．A tota1of189patientswithinitia1pulmonary tuberculosisweredividedintofourgroupswhotookantiut． berculoticscombinedwithJian’ganle，HuganPian，glucurono1acton