《Expression of Hpa and CD222 in bladder carcinoma and analysis of clinico-pathologic correlation.》.pdf

ExpressionofHpaandCD222inbladderca andanalysisofCIiniC0一pathO10giCcorrelation ShuhongShi，HuiZhang DepartmentofBloodandOncology，ShaoyangCentralHospital，Shaoyang422000，China Received：25April2014／Revised：3May2014／Accepted：15May2014 @HuazhongUniversityofScienceandTechnology2014 Abstract Objective：Ourstudyaimedloinvestigatelherelationshipsbetweenlheclinico．pathologicfeaturesandlhehepa． ranase(Hpa)andCD222expressionsjnbladdercarcinoma．Methods：TheexpressionsofHpaandCD222jn95bladder carcinomaspecimensand20paraneoplasticbladderlissues(controls)wereassessedusinglheimmunohistochemicafstain— ingmethod．Results：ThepositiveexpressionratesofHpaandCD222inbladdercarcinomawere68．42％and61．05％． respectively．ThepositiverateofHpawassignificantlyhigherinfhecarcinomaspecimensfhaninfhecontro}specimensfP O．01)．Similarly，lheHpaexpressioninlheinvasivebladdercarcinomawassignificantlyhigherlhanlhalinlhenon—invasive bladdercarcinoma(P0．01)．ApositivecorrelationwasobservedbewteenlheexpressionsofHpaandCD222(PO．05)． TheexpressionsofHpaandCD222weresignificantlycorrelatedwithfymphaticinvasionandTNMstagingfP0．05)．The 5-yearsurvivaIratewassignificantlyhigherinnegativeexpressionoflheHpagrouplhanlhalinlhepositiveexpressiongroup (P0．05)．Comparedwithlhenon—co—positiveexpressiongroup．1he5-yearsurvivaIrateinIheco—positiveexpressionofHpa andCD222groupwassignificantly10wetfP0．o5)．Conclusion：HighHpaandCD222expressionsinfumorfissueswere associatedwithlheoccurrenceanddevelopmentofbladdercarcinoma．OurresultsprovidehelpfuIinformationforlhefurther diagnosisandtherapyofbladdercarcinoma． Keywords bladdercarcinoma；heparanase；CD222 r C Bladdercarcinomaisthemostcommonmalignanttu— receptor．CD222isalsocalledinsulin—likegrowthfactor morsofgenitourinarysystem inChina．Theincidenceand IIreceptor．Itis