《Heparin inhibits burn-induced spleen cell apoptosis by suppressing interleukin-1 expression.》.pdf
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《Heparin inhibits burn-induced spleen cell apoptosis by suppressing interleukin-1 expression.》.pdf
ChineseMedicalJournal2014:127(i3) 2463
— —
Originalarticle
Heparininhibitsburn-inducedspleencellapoptosisbysuppressing
i0nterlleullo-n-1eXDressl●on
ZhaoSongfeng,ZhangXiao,ZhangXiaojian,ShiXiuqin,YuZujiangandKanQuancheng
Keywords:burn,spleen,apoptosis,‘heparin,。interleukin—J『
BackgroundEpidermalburninjurymaytriggersignificantapoptosisofthespleencells,whichmightbecausedbyaburn.
induced systemicinflammatory reaction.Heparinhasbeenshowntopossessanti.inflammatoryproperties
. 1nterleukin1
(1L_1)iscentrallyimportantamongpro-inflammatorycytokines.Wehypothesizedthatheparinmightinhibitburn.induced
apoptosisinthespleenviasuppressionoftheIL.1pathway.
Methods BurninjurywasperformedonIL一1R+/+(IL一1receptorwild.typemouse)andIL.1R-/一(IL.1receptorknock.
outmouse)mice,andtheywerethentreatedwithheparin,salineorlL-1receptorantagonistlLRa.Apoptosis,lL.1aand
IL-113expressionwereassessedinthespleensandserum.SurvivaIcurveanalysiswasfurtherappliedtoelucidatethe
mechanism ofheparin’sprotectiveproperties.
Results Burninducedsignificantapoptosis(sham:3.6%±2.1%vs.burn:28.8%±5.9%:P0.001)andremarkable
expressionoIL-1aandlL-131inthemousespleensandserum,Heparinreducedtheburn.inducedapoptosisinthespleens
(heparintreated:8_6%±3.4%,P0.005),whichcouldbeblockedbylL.1Ra.HeparinmarkedlydecreasedbothIL.1aand
lL-131expressioninthespleensandserumofburnedmice.fL.1R-/-micedemonstratedconsiderablyIessapoptosisinthe
spleensandhadahighersurvivaIrateafterburns.Heparindidnotsignificantlydecreaseapoptosisinthespleenandthe
mortalityrateinlL一1R4-miceafterburns.
Conclusion Heparininhibitsburn—inducedapoptosisofthespleencellsbysuppressinglL.1expressioninmice.
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