《Investigation on the optical scan condition for imaging of multi-slice spiral CT liver perfusion in rats.》.pdf

4742 ChinMedJ2013：126 2《4) Originalarticle Investigationontheopticalscanconditionforimagingofmulti-·slice spiralCTliverperfusioninra BAIRong-jie，WANGJin—e，JIANGHui-jie，HAOXue-jia，DONGXu—peng，HUANGYa—huaandWEILai Keywords：multi—slicespiralCTperfusion，。scanprotocol,rats，h‘emod)namics BackgroundMultisliceCT Iiverperfusionhasbeenwidelyused inexperimentalstudiesofhemodynamicchangesin Iiverlesions．andisusuallyperformedasanadjuncttoaconventionalCTexaminationbecauseofitshightemporaland spatialresolution，simpleprotocol，goodreproducibility，andabilitytomeasurehemodynamicchangesoflivertissues atthecapillaryJeve1．Experimentalratmodels，especiallythoseofinducedIivercancer，areoftenused instudiesof hemodynamicchangeslnlivercancer．Carcinogenesisin ratshasasimilarpathologicalprogressionandcharacteristics resemblingthoseinhumanIivercancer；asaresult．ratmodelsareoftenusedasideaIanimaImodelsinthestudyof human livercancer．However,liverperfusionimaging inratsisdifficulttoperform．becauserats’IiversaresosmalIthat differenlconcentrations，flow rates，anddoseofcontraslagentsduringtheCTpe sionscanningcaninfluencethequality ofIiverperfusionimagesinrats．Thepurposeofthisstudy．therefore．wasto investigatetheoptimalscanprotocolfor theimagingofhepaticperfusionusingadeconvolutionmathematicalmethodinratsbycomparingtheresultsofratsin differentinjectionconditionsofthecontrastagent．includingconcentration。rateandtime． Methods PlainCTSCaRconditionsineighty2．month．oldmaleW istarratswere5．0mm slicethickness，5．0mm lnterval， 1．0pitch，120kV tubevoltage，60mA tubecurrent，512x512matrix，andFOV9．6cm。Perfusionscanningwascarried oufwithdifferenlconcentrationsofdiatrizoate(19％，38％，57％，and76％)，differenlinjectionrates(0．3and0．5mils)， anddifferentinjectiontimes(1，2—3，4-5，and6seconds)．Theaboveconditionswererandomlymatchedandadjustedto determinelhe