《Involvement of aquaporins in a mouse model of rotavirus diarrhea.》.pdf

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《Involvement of aquaporins in a mouse model of rotavirus diarrhea.》.pdf

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VIROLOGICASINICA2014，29(4)：211-217 DOI10．1007／sl2250．014．3469一z ESEARCHARTICLE Involvementofaquaporinsinamousemodelofrotavirusdiarrhea Meiw nCao ，MinYang，ZhiyingOu’DingyouLi，LanlanGeng’PeiyuChen’HuanChen’Sitang ，，，， Gong。 1．DepartmentofGastroenterology，GuangzhouWomenandChildren’sMedicalCenter ． Guangzhou 510623，China 2．DepartmentofGastr0enterOIOgy，Children’sMercyHospital，UniversityofMissouriKansasCitySchool ofMedicine，2401Gillham Road，Kansas64108，USA Rotavirusdiarrheajsamajorworldwidecauseofjnfantilegastroenterjtjs；however,themechanism responsibleforintestinaIfluid Iossremainsunclear．WatertransferacrosstheintestinaIepithelial membraneseemstoOCCUrbecauseofaquaporins(AQPs)．AccumuIatingevidenceindicates thatalterationsinAQPsmayplayan importantroleinpathogenesis．Here．wefocusonchanges jnAQPsinamousemodeIofrotavirusdiarrhea．Jnthepresentstud~ 32of35micedeveloped diarrheaandm ilddehydrationwithin24hoursafterjnfectionwithrotavirusstrainSA11．1ntestinaI epithelialcelIsdemonstrated cytoplasmicvacuolation，malalignedvIlli，andatrophy．AQP1 expressionwassignificantly attenuated intheileum and colon in comparison withcontrols： Iikewise，AQP4and-8proteinexpressionweresignificantlydecreasedinthecolonofrotavirus diarrhea-infectedmice．Incontrast，AQP3proteinexpressionwassignificantly increased inthe colonofrotavirus-infectedmice incomparisonwith controls．Theseresultsjndicatethatrotavirus diarrheaisassociatedwiththedownregulationofAQP1，-4，and-8expression．Therefore，AQPs playan importantrole inrotavirusdiarrhea． KEYW ORDS rotavirus；aquaporin；AQP；diarrhea；mice；intestine resultinginthemalabsorpt