《Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone.》.pdf
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《Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone.》.pdf
RIad■I●Of●rleaUenCyab■I■at■I■OnOrm l’CrOW aVe ab■-lat■0Ioncom b■0lnea■
withtranSCatheterarteriaIchemoembolizationintreatmentof
hepatOCe¨ularcarcinomabycomparingwithradiofrequency
ablationalone
Y0n angYi,YufengZhang,QiangWei,LiangZhao,JianboHan,YanSong,YingDing,Guilan
Lu,JunmaoLiu,HuaiyingDing2,FengDai,‘XiaojunTanV
DepamnentofHepatobiliarySurgery;DepartmentofMedicalImaging,theSecondAffiliatedHospitalofSoutheastUniversity,Nanjing210003,China
Correspondingto:YongxiangYi.DepartmentofHepatobiliarySurgery,theSecondAffiliatedHospitalofSoutheastUniversiyt,Nanjing210003.China.
Email:ian01269@126.com.
Objective:T0compareradiofrequencyablationfRFA)ormicrowaveablation(MWA)andtranscatheter
arteria1chemoembolization(TACE、widlRFAorMⅥ monotllerapyinhepatocellularcarcinoma(HCC).
Methods:Aprospective.randomized.controlledtrialwasconductedon94patientswithHCC 7cm ata
singletertiaryreferralcenterfromJune2008toJune2010attheDepartmentofHepatobiliarySurgery,hte
SecondAffiliatedHospitalofSoutheastUniversity.ThepatientswererandomlyassignedintohteT CE—
RFAorTACE—MW_A (combinedtreatmentgroup)andtheRFA—aloneorMWA—alonegroups(control
group).Theprimaryendpointwasoverallsurviva1.Thesecondaryendpointwasrecurrence—freesurviva1.
andhtetertiaryendpointwasadverseefflects.
Results:Untilhtetimeofcensor,17patientsintI1cTACE—RR orTACE—M WA grouphaddied.The
medianofllow—uDtimeofhtepatientswhowerestillaliveforhte,rACE—RF orTACE—M、vA groupwas
47.5~11.3morthts(range,29to62monhts).The1一,3一and5-yearoverallsurvivalofrtheTACE—RFAor
TACE—MⅥ,Agroupwas93.6%.68.1% and61.7%.respectively.Twenty—fivepatientsinhteRFAorMW_A
rgouphaddied.Themedianfollow-uptimeofthepatientswhowerestillalireofrhteRF orM、^ rgoup
was47.0+I2.9mOBths(range.28to62monhts).Thel-93一and5-yearoverallsurvivalofrtheRFAorMⅥ
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