《Evaluation of lipid peroxidation inhibition and free radical scavenging abilities of 5,6,7-tfimethoxy dihydroflavonols》.pdfVIP

Available online at Chinese Chemical Letters 20 (2009) 1187–1190 /locate/cclet Evaluation of lipid peroxidation inhibition and free radical scavenging abilities of 5,6,7-trimethoxy dihydroflavonols Ke Xin Huang a, Yu Bing Feng b, Wei Yao a,c, Lei Xiang Yang b, Feng Wang b, Cb,d b b b b, * Hai Bo Li , Su Zeng , Jing Xu Gong , Ming Hui Hu , Yu Zhao , H_NE5E Xiu Mei Wu a, Xiao Kun Li a,*, Jia Qu a a Key Laboratory of Southern Zhejiang TCM RD, Pharmacy School of Wenzhou Medical College, Wenzhou 325035, China b College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China c Zhejiang Chemical Industry Research Institute, Zhejiang Chem-Tech Group Co., Ltd., Hangzhou 310023, China d College of Pharmacy and Pharmaceutical Sciences, Florida AM University, FL 32307, USA Received 2 March 2009 This paper is dedicated to Professor Zhong Jian JIA at Lanzhou University on the occasion of her 80th birthday celebration. Abstract Four naturally rare 5,6,7-trimethoxy-2,3-cis-dihydroflavonols (3–6) and two 5,6,7-trimethoxy-2,3-trans-dihydroflavonols (7–8) were designed and synthesized. Their antioxidative properties were evaluated by way of examining their scavenging capacities towards DPPH and O2 free radicals, as well as by measuring their inhibitory ability against LPO. Both t