Atlas-BasedClassification-NationalAllianceforMedical.pptVIP

Atlas Based Classification Work in Progress: Other TBI Cases More Information /projects/abc * * * * ABC: Atlas-Based Classification Marcel Prastawa and Guido Gerig Scientific Computing and Imaging Institute University of Utah ABC Atlas template with spatial priors for tissue categories Tissue Classification Atlas to subject warping Inhomogeneity correction ABC: Fully Automatic Workflow Spatial normalization (linear): intermodality, atlas K. Van Leemput, F. Maes, D. Vandermeulen, P. Suetens, P., Automated model-based tissue classification of MR images of the brain, IEEE TMI, 18(10) 1999 N. Moon, E. Bullitt, K. van Leemput, G. Gerig, Automatic Brain and Tumor Segmentation, Proc. MICCAI ‘02, Springer LNCS 2488, 09/2002 ABC: Properties Fully automatic, no user interaction required Repeatable, reproducible results Arbitrary #channels/modalities: Co-registration Integrates brain stripping, bias correction and segmentation into one optimization framework ≠ set of separate procedures Atlas to subject warping: diffeomorphic fluid flow registration Generic framework: Needs image(s) and prob. atlas → RUN Rigorous validation and testing Run time: Affine atlas matching: 0.5h, deformable: 2-3hrs In progress: Extension to pathologies Typical Output: Registration and Segmentation of T1/T2 3D wm surface 3D cortical surface T1 T2 Brain Tissue T1 T2 Brain Tissue “Byproduct”: Bias inhomogeneity correction T1 registered Corrected image Bias field 3T 1.5T “Byproduct”: Brain Stripping MRI segmentation: ICV as result of brain segmentation (gm+wm+csf) DTI: Brain masking via tissue segmentation of B0 image. “Byproduct”: Co-Registration of structural MRI for visualizing multi-contrast data MPrage+gad GRE-bleed TSE FLAIR SWI TBI case courtesy J. v Horn , D. Hovda, UCLA ABC in human traveling phantom across-site MRI calibration Phantom1 Phantom2 Courtesy ACE-IBIS autism study, Piven, UNC MRI and DTI scans of 2 traveling phantoms annually at 6 sites Robust framework for detecting calibrat