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Faecalibacterium prausnitzii在结肠炎相关结直肠癌发生中的作用.pdf
胃肠病学 2015年第 20卷第9期 · 517 ·
· 论 著 ·
Faecalibacterium
相关结直肠癌发生中的作用木
谢丽娟 卢学嘉 于成功 。
南京大学医学院附属鼓楼医院消化科 (210008) 南京鼓楼医院集团仪征医院消化科
背景：Faecalibacteriumprausni~ii(Fp)是人类肠道中数量最 占优势的细菌之一，与结肠炎相关结直肠癌 (CAC)
的发生密切相关。目的：研究 Fp对CAC发生的影响，并初步探讨可能的机制。方法：应用氧化偶氮甲烷 (AOM)和
葡聚糖硫酸钠 (DSS)诱导CAC模型，将 52只C57BL／6J小鼠随机分为A组 (AOM+DSS)、B组 (AOM+DSS十
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