慢性肾脏病诊治新常态创新.ppt

* * 阻断RAS对控制血压是非常有效的。这里显示的是Losartan和依那普利。可以看到，应用Losartan50mg/天，可以使血压下降10mmHg，增加至100mmHg可以继续下降一些，停药后恢复原先水平。用依那普利10mg/天，血压下降也是10mmHg左右，加量至20mg/天也会使血压有进一步下降，程度较Losartan相似，因此ACEI和ARB在控制血压方面的作用是相似的。 * * * Ang I and Ang II levels in renal interstitial fluid, plasma, and kidneys in which microdialysis probes were implanted in anesthetized rats (n=7). Renal interstitial concentrations of Ang I and Ang II were calculated based on equilibrium rates determined in vitro. * * The DIOVAN Reduction of Proteinuria (DROP) study assessed whether high doses of valsartan were superior to conventional doses for