人类可溶性环氧化物水解酶抑制剂的研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc1107132 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 人类可溶性环氧化物水解酶抑制剂的研究进展 黄少胥 王 勇 龙亚秋* ( 中国科学院上海药物研究所合成化学实验室 上海 201203) 摘要 高血压是现代人的常见疾病. 虽然有很多不同机理的降压药在临床使用, 但是由于个体的差异性, 高血压的治 疗越来越倾向于个体化治疗, 因此降压药的使用也不仅仅局限于血压的降低. 人类可溶性环氧化物水解酶抑制剂最大 的优势在于其在降压的同时还具有显著的抗炎作用. 详细地阐述了人类可溶性环氧化物水解酶抑制剂从早期的环氧结 构类型到第三代脲类结构的发展过程和近期研究进展. 关键词 可溶性环氧化物水解酶; 花生四烯酸环氧化物; 抑制剂; 1,3-二取代脲; 高血压; 炎症 Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors Huang, Shaoxu Wang, Yong Long, Yaqiu* (Laboratory of Medicinal Chemistry, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203) Abstract Hypertension is a common illness nowadays. Although a wide variety of antihypertensive agents are available in the market for the treatment of hypertension, the antihypertensive treatment tends to be individualized, and the treatment should exceed the limitation of lowering blood pressure only. Compared to other antihypertensive agents, the advantage of human soluble epoxide hydrolase inhibitors (HsEHIs) is that they can not only reduce the blood pressure, but also have re- markable anti-inflammatory effects. Herein, the development of human soluble epoxide hydrolase inhibitors is reviewed from early epoxide HsEHIs to the third generation of urea HsEHIs. Keywords soluble epoxide hydrolase; epoxyeicosatrienoic acid; inhibitors; 1,3-disubstituted urea; hypertension; inflamma-