A Fragment of ORFs Around the Direct Repeat (DR) Region of Mycobacterium tuberculosis is Absent From the Other Sequenced Mycobacterial Genomes Implications for the Evolution of the DR Region.pdfVIP

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A Fragment of ORFs Around the Direct Repeat (DR) Region of Mycobacterium tuberculosis is Absent From the Other Sequenced Mycobacterial Genomes Implications for the Evolution of the DR Region.pdf

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A Fragment of ORFs Around the Direct Repeat (DR) Region of Mycobacterium tuberculosis is Absent From the Other Sequenced Mycobacterial Genomes Implications for the Evolution of the DR Region.pdf

Comparative and Functional Genomics Comp Funct Genom 2004; 5: 116–122. Published online in Wiley InterScience (). DOI: 10.1002/cfg.380 Short Communication A fragment of 21 ORFs around the direct repeat (DR) region of Mycobacterium tuberculosis is absent from the other sequenced mycobacterial genomes: implications for the evolution of the DR region Karina Caimi and Angel Cataldi* Institute of Biotechnology, CICVyA-INTA Castelar, Argentina *Correspondence to: Abstract Angel Cataldi, Instituto de ´ The direct repeat (DR) region is a singular locus of the Mycobacterium tuberculosis Biotecnologıa, CICVyA/INTA, Los ˜ complex genome. This region consists of 36 bp repetitive sequences separated by Reseros y Las Cabanas, 1712 Castelar, Argentina. non-repetitive unique spacer sequences. Around this region there are several genes E-mail: acataldi@.ar coding for proteins of unknown function. To determine whether the M. smegmatis, M. avium, M. marinum and M. leprae genomes contain sequences and ORFs similar to those of the DR locus of the M. tuberculosis complex, we analysed the corresponding regions in these species. As a ﬁrst step, some conserved genes that ﬂank the DR genes [Rv2785c (rpsO ), Rv2786c (ribF ), Rv2790c (ltp1 ), Rv2793c (truB ), Rv2800, Rv2825, Rv2828, Rv2831 (echA16 ), Rv2838 (rbfA) and Rv2845 (proS )] were used as markers to locate the corresponding orthologues in M. smegmatis, M. avium, M. marinum and M. leprae in silico. Most of these