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A Model of Dispersion in Perifusion Systems.pdf
Q 2001 OPA (Overrear Publishers Association) NV
.Journal of Thronncai Medrcme. Vol. 3, pp 191-211 Published by license under
Reprints ava~lahlt:dlrectly from [he publiiher the Cordon and Breach Sc~ence
Photocopymg permmed by l~censeonly Puhl~rhers
Impnnt.
A Model of Dispersion in Perifusion Systems
PAUL R. SHORTEN*and DAVID J.N. WALL
Biomathematics Research Centre, Department of Mathematics Statistics, Universiryof Canterbuq, Private Bag 4800, Chrrsrchurch, I ,
New Zealand
(Received 4 September 2000)
The perifusion apparatus is an experimental tool used to model information transfer in endo-
crine systems. The major drawback of the penfusion system derives from the dispersion, dif-
fusion and mixing of the hormone within the apparatus which distort the original released
hormone concentration profile. In this paper we develop a mathematical model of the perifu-
sion system that accounts for a number of observable features in the measured secretory pro-
file. We also consider associated inverse problems, the solution of which enhance perifusion
data measurements and unmask the underlying secretory e
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