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ABO Incompatible Kidney Transplantation—Current Status and Uncertainties.pdf
Hindawi Publishing Corporation
Journal of Transplantation
Volume 2011, Article ID 970421, 11 pages
doi:10.1155/2011/970421
Review Article
ABO Incompatible Kidney Transplantation—Current Status
and Uncertainties
Milljae Shin and Sung-Joo Kim
Division of Transplant Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine,
No. 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea
Correspondence should be addressed to Sung-Joo Kim, kmhyj.kim@
Received 14 June 2011; Accepted 23 October 2011
Academic Editor: Eric Thervet
Copyright © 2011 M. Shin and S.-J. Kim. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
In the past, ABO blood group incompatibility was considered an absolute contraindication for kidney transplantation. Progress
in defined desensitization practice and immunologic understanding has allowed increasingly successful ABO incompatible
transplantation during recent years. This paper focused on the history, disserted outcomes, desensitization modalities
and protocols, posttransplant immunologic surveillance, and antibody-mediated rejection in transplantation with an ABO
incompatible kidney allograft. The mechanism underlying accommodation and antibody-mediated injury was also described.
1. Introduction 2. History of ABO-Incompatible
Kidney Transplantation
The most effective treatment of end-stage renal disease is
kidney transplantation, but a severe donor shortage has sig-
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