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A Cellular Automaton Model of Brain Tumor Treatment and Resistance.pdf
Journal of Theoretical Medicine, 2002 Vol. 4 (4), pp. 223–239
A Cellular Automaton Model of Brain Tumor Treatment and
Resistance
a b a,c,
JONATHAN E. SCHMITZ , ANURAAG R. KANSAL and SALVATORE TORQUATO *
aDepartment of Chemistry, Princeton University, Princeton, NJ 08544, USA; bDepartment of Chemical Engineering, Princeton University, Princeton,
NJ 08544, USA; cPrinceton Material Institute, Princeton University, Princeton, NJ 08544, USA
(Received 22 May 2002; In final form 2 January 2003)
We have extended an automaton model of brain tumor growth to study the effects of treatment. By varying
three treatment parameters, we can simulate tumors that display clinically plausible survival times. Much
of our work is dedicated to heterogeneous tumors with both treatment-sensitive and treatment-resistant
cells. First, we investigate two-strain systems in which resistant cells are initialized within predominantly
sensitive tumors. We find that when resistant cells are not confined to a particular location, they compete
more effectively with the sensitive population. Moreover, in this case, the fraction of resistant cells within
the tumor is a less important indicator of patient prognosis when compared to the case in which the
resistant cells are scattered throughout the tumor. In additional simulations, we investigate tumors that are
initially monoclonal and treatment-sensitive, but that undergo resistance-mutations in response to
treatment. Here, the tumors wit
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