Advanced Corneal Cross-Linking System with Fluorescence Dosimetry.pdfVIP

Hindawi Publishing Corporation Journal of Ophthalmology Volume 2012, Article ID 303459, 6 pages doi:10.1155/2012/303459 Research Article Advanced Corneal Cross-Linking System with Fluorescence Dosimetry Marc D. Friedman, Radha Pertaub, David Usher, Evan Sherr, Pavel Kamaev, and David Muller Research and Development, Avedro Inc., Waltham, MA 02451, USA Correspondence should be addressed to Marc D. Friedman, mfriedman@ Received 3 February 2012; Revised 27 April 2012; Accepted 7 May 2012 Academic Editor: David A. Wilkie Copyright © 2012 Marc D. Friedman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. This paper describes an advanced system that combines corneal cross-linking with riboflavin with fluorescence dosimetry, the ability to measure riboflavin diffusion within the cornea both before and during UVA treatment. Methods and Results. A corneal cross-linking system utilizing a digital micromirror device (DMD) was assembled and used to measure diffusion coefficients of −7 2 0.1% riboflavin in 20% dextran in porcine eyes. A value of (3.3 ± 0.2) × 10 cm /s was obtained for the stroma. Diffusion coefficients for the transepithelial formulation of 0.1% riboflavin in 0.44% saline and 0.02% BAK were also measured to be −8 2 −7 2 4.7 ± 0.3 × 10 cm /s for epithelium only and (4.6 ± 0.4) × 10 cm /s for stroma only. Riboflavin consumption during a UVA treatment was also demonstrated. Conclusion