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Analysis of Lackers Model with an Ageing Factor for the Control of Ovulation and Polycystic Ovary Syndrome.pdf
Journal ~ T i i e o , r i r c aMedicine.l Vol 3. pp. 237-270 02001 OPA (Ovenrai Puhliahrri .4rioclauon) N.V.
Repr~ntsava~labled~rectl)from the publisher Published by license under
Phomcopymg permitted by Ilcenfe only the Gordon and Breach Sc~encePuhhshers mpnnt,
a lnember of the Taylor Francis Gioup
All rlghti re\er\ed
Analysis of Lackers Model with an Ageing Factor for the
Control of Ovulation and Polycystic Ovary Syndrome
Centrefor Nonlinear Dynamics and its Applcrationsf, University College London, Gower Street, London, WClE 6BT, U.K.
(Rereived 3 May 2000; Revised 15 January 2001)
In the present paper, we develop an extensive theoretical analysis of the deterministic model for
the control of ovulation in mammals proposed by Mariana et al., (1994),which is an extension of
Lackers model. Mariana et al. incorporated an age decaying factor in follicle maturity, and kept
follicle growth law as Lacker first proposed. However, they produced only some numerical
examples simulating the new advantages of their model. As a result of the present analysis, we
propose an alternative understanding of folliclegenesis, pre-ovulatory follicle selection in
mammals, and polycystic ovary syndrome (PCOS) in women.
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