Application of a New Processing Method to Post-LDL-apheresis Data.pdfVIP

Journal of Theoretical Medicine, 2002 Vol. 4 (3), pp. 191–196 Application of a New Processing Method to Post-LDL-apheresis Data a b, c b FRANCO CORSINI , ARRIGO F. G. CICERO *, ANTONIA GIANNUZZI and ANTONIO GADDI aMedical and Surgical Paediatric Sciences Complex Unit, University of Bologna, Italy; bClinical Medicine and Applied Biotechnology Department “D. Campanacci”, Atherosclerosis centre “G. Descovich”, University of Bologna, Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy; cClinical Medicine and Applied Biotechnology Department “D. Campanacci”, University of Bologna, Italy (Received 18 October 2001; In final form 29 July 2002) Our aim was to elaborate a method to optimise treatment intervals for the individual low-density lipoprotein (LDL)-apheresis treated patients. After each treatment, plasma LDL concentrations show a time-related increase with a decreasing speed until a maximum level. We searched to interpret the post- LDL-apheresis experimental data trend as the physical process that produces the observed curve, so that the fitting presupposed theoretical function is a direct consequence of the physic process, because to establish the better time. Applying the proposed fitting method to a succession of 15 samples obtained from the mean of six plasmapheresis executed on five different subjects, small estimate standard error (5 mg/dl) and relative error (1.7%) with a dispersion evidently related to the experimental error were observed. Obviously, applying the