Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players.pdfVIP

Hindawi Publishing Corporation Advances in Bioinformatics Volume 2012, Article ID 453513, 9 pages doi:10.1155/2012/453513 Research Article Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players 1 ¨ 2 3 1 Olga Papadodima, Allan Sirsjo, Fragiskos N. Kolisis, and Aristotelis Chatziioannou 1 Metabolic Engineering and Bioinformatics Program, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas. Constantinou Avenue, 11635 Athens, Greece 2 ¨ ¨ Division of Clinical Medicine, School of Health and Medical Sciences, Orebro University, Orebro SE-701 82, Sweden 3 Biotechnology Laboratory, School of Chemical Engineering, Zografou Campus, National Technical University of Athens, 15780 Athens, Greece ¨ Correspondence should be addressed to Allan Sirsjo, allan.sirsjo@oru.se and Aristotelis Chatziioannou, achatzi@eie.gr Received 25 May 2012; Accepted 21 September 2012 Academic Editor: Konstantina Nikita Copyright © 2012 Olga Papadodima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Atherosclerosis is a multifactorial disease involving a lot of genes and proteins recruited throughout its manifestation. The present study aims to exploit bioinformatic tools in order t