原创力文档Development and Validation of a Mathematical Model to Describe Anti-Cancer Prodrug Activation by Antibody-Enzyme Conjugates.pdfVIP
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Development and Validation of a Mathematical Model to Describe Anti-Cancer Prodrug Activation by Antibody-Enzyme Conjugates.pdf
Journal of Theurerrcui Medicine. Vol 2. p p . 93- 111 @ 2000 OPA (Over5cas Publ~shersAsiociation) N.V.
Repr~ntsava~labledircctly from the publirher Publibhed by I~censeunder
Photocopying perm~ttedby lisenre only the Gordon and Breach Science
Publishers mpnnt.
Prmted In Malaysia
Development and Validation of a Mathematical Model
to Describe Anti-Cancer Prodrug Activation by
Antibody -Enzyme Conjugates
TRACHETTE L. JACKSON, PETER D. SENTERb and JAMES D. MURRAYc
alnstitutefor Matltematics and itr Applications, Universiy of Minnesota, 426 Lind Hall, 207 Church Street S.E., Minneapolis, M N
55455; b~epartmentof Applied Mathematics, University of WashingtonBox 352420, Seattle WA 98195-2420; CSeattleGenetics, Inc.,
22215 26th Avenue SE, Bothell, WA 98021
(Received 6 October 1998; Infinal form I April 1999)
A mathematical model has been developed for a two-step approach to cancer chemotherapy
involving the use of targeted monoclonal antibody-enzyme conjugates for the selective
activation of anti-cancer prodrugs. Theoretical analysis and numerical simulation are
used to characterize critical parameters
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