Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats.pdfVIP

Hindawi Publishing Corporation Journal of Toxicology Volume 2010, Article ID 206057, 12 pages doi:10.1155/2010/206057 Research Article Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats Ingeborg M. Kooter,1, 2 Miriam E. Gerlofs-Nijland,2 A. John F. Boere,2 Daan L. A. C. Leseman,2 Paul H. B. Fokkens,2 Henri M. H. Spronk,3 Kim Frederix,3 Hugo ten Cate,3 Ad M. Knaapen,4, 5 Hendrik J. Vreman,6 and Flemming R. Cassee2 1 Department of Environment, Health and Safety, TNO Built, Environment and Geosciences, Princetonlaan 6, 3584 CB Utrecht, The Netherlands 2 Centre for Environmental Health Research, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands 3 Department of Internal Medicine, Laboratory of Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, 6229 ER Maastricht, The Netherlands 4 Department of Health Risk Analysis and Toxicology, Nutrition and Toxicology Research Institute (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands 5 Organon, Schering Plough, 5342 CC Oss, The Netherlands 6 Division of Neonatal Developmental Medicine, Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305-5208, USA Correspondence should be addressed to Ingeborg M. Kooter, ingeborg.kooter@tno.nl Received 16 June 2010; Accepted 27 September 2010 Academic Editor: JeanClare Seagrave Copyright © 2010 Ingeborg M. Kooter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study