ession of Proinflammatory and Regulatory Cytokines via NF-κB and MAPK-Dependent and IFN Regulatory Factor-3-Independent Mechanisms in Human Primary Monocytes Infected by Mycobacterium tuberculosis.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2011, Article ID 841346, 8 pages doi:10.1155/2011/841346 Research Article Expression of Proinflammatory and Regulatory Cytokines via NF-κB and MAPK-Dependent and IFN Regulatory Factor-3-Independent Mechanisms in Human Primary Monocytes Infected by Mycobacterium tuberculosis 1 1 1 ´ 1, 2 Elena Giacomini, Maria Elena Remoli, Marta Scandurra, Valerie Gafa, Manuela Pardini,1 Lanfranco Fattorini,1 and Eliana M. Coccia1 1 Dipartimento di Malattie Infettive, Parassitarie ed Immmuno-mediate, Istituto Superiore di Sanita, I-00161, Rome, Italy ` 2 EA4303 “Inflammation et Immunite de l’epithelium Respiratoire”, IFR53, UFR de Pharmacie, ´ ´ ´ Universite de Reims Champagne-Ardenne, 51096 Reims, France ´ Correspondence should be addressed to Eliana M. Coccia, eliana.coccia@iss.it Received 14 October 2010; Accepted 26 November 2010 Academic Editor: James Triccas Copyright © 2011 Elena Giacomini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Knowledge of the molecular events regulating the innate response to Mycobacterium tuberculosis (Mtb) is critical for understanding immunological pathogenesis and protection from tuberculosis. To this aim, the regulation and the expression of regulatory and proinflammatory cytokines