Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals.pdfVIP

Hindawi Publishing Corporation Journal of Parasitology Research Volume 2011, Article ID 512154, 8 pages doi:10.1155/2011/512154 Review Article Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals Stefan Michael Geiger,1 Ricardo Toshio Fujiwara,1, 2 Paula Albuquerque Freitas,1 1 1 ˆ 1 Cristiano Lara Massara, Omar dos Santos Carvalho, Rodrigo Correa-Oliveira, and Jeffrey Michael Bethony1, 3 1 Centro de Pesquisas Ren´e Rachou, Fundac¸˜ao Oswaldo Cruz, Avenida Augusto de Lima 1715, 30190-002 Belo Horizonte, MG, Brazil 2 Departamento de Parasitologia, Instituto de Ciˆencias Biol´ogicas, Universidade Federal de Minas Gerais, Avenida Antˆonio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil 3 Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA Correspondence should be addressed to Stefan Michael Geiger, stefan@cpqrr.fiocruz.br Received 30 November 2010; Revised 18 March 2011; Accepted 29 March 2011 Academic Editor: Takeshi Agatsuma Copyright © 2011 Stefan Michael Geiger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We compared the effects of larval and adult worm excretory-secretory (ES) products from hookworm on the proliferative responses and cytokine secretion in peripheral blood mononuclear cells (PBMCs) from hookwormpatients and egg-negative,