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From Experimental Approaches to Computational Techniques A Review on the Prediction of Protein-Protein Interactions.pdf

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From Experimental Approaches to Computational Techniques A Review on the Prediction of Protein-Protein Interactions.pdf

Hindawi Publishing Corporation Advances in Artiﬁcial Intelligence Volume 2010, Article ID 924529, 15 pages doi:10.1155/2010/924529 Review Article From Experimental Approaches to Computational Techniques: A Review on the Prediction of Protein-Protein Interactions Fiona Browne,1 Huiru Zheng,1 Haiying Wang,1 and Francisco Azuaje2 1 Faculty of Computing and Engineering, University of Ulster Jordanstown Campus, Shore Road, Newtownabbey, Co. Antrim BT37 0QB, UK 2 Laboratory of Cardiovascular Research, Public Research Centre for Health (CRP-Sante), 120, route d’ArlonL-1150, Luxembourg ´ Correspondence should be addressed to Huiru Zheng, h.zheng@ulster.ac.uk Received 15 September 2009; Revised 13 November 2009; Accepted 6 January 2010 Academic Editor: Daniel Berrar Copyright © 2010 Fiona Browne et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A crucial step towards understanding the properties of cellular systems in organisms is to map their network of protein-protein interactions (PPIs) on a proteomic-wide scale completely and as accurately as possible. Uncovering the diverse function of proteins and their interactions within the cell may improve our understanding of disease and provide a basis for the development of novel therapeutic approaches. The development of large-scale high-throughput experiments has resulted in the production of a large volume of data which has aided in the uncovering of PPIs. However, these data are often erroneous and limited in interactome coverage. Therefore, additional experimental and c