Fundamental Dynamical Modes Underlying Human Brain Synchronization.pdfVIP

Hindawi Publishing Corporation Computational and Mathematical Methods in Medicine Volume 2012, Article ID 912729, 8 pages doi:10.1155/2012/912729 Research Article Fundamental Dynamical Modes Underlying Human Brain Synchronization Catalina Alvarado-Rojas and Michel Le Van Quyen ´ Centre de Recherche de l’Institut du Cerveau et de la Moelle Epiniere (CRICM), INSERM, UMRS 975 and CNRS UMR 7225, UPMC, ` Hopital de la Pitie-Salpetriere, 75651 Paris cedex 13, France ˆ ´ ˆ ` Correspondence should be addressed to Michel Le Van Quyen, quyen@t-online.de Received 19 November 2011; Revised 15 January 2012; Accepted 1 March 2012 Academic Editor: Ralph G. Andrzejak Copyright © 2012 C. Alvarado-Rojas and M. Le Van Quyen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Little is known about the long-term dynamics of widely interacting cortical and subcortical networks during the wake-sleep cycle. Using large-scale intracranial recordings of epileptic patients during seizure-free periods, we investigated local- and long-range synchronization between multiple brain regions over several days. For such high-dimensional data, summary information is required for understanding and modelling the underlying dynamics. Here, we suggest that a compact yet useful representation is given by a state space based on the first principal components. Using this representation, we report, with a remarkable similarity across the patients