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Gradient Method for Finding Optimal Scheduling in Infinite Dimensional Models of Chemotherapy.pdf
Joirrnal of Theoreti~~iliMedt~cnr.Vol. 3, pp. 25-36 02000 OPA AOverseasPublisherr Associatmn) N V
Repr~ntsava~labledlrectly from the publtsher Published by license under
Photocopytng pernutted by l~censeonly the Gordon and Breach Sc~ence
Publtrhcrs imprint
Pnntsd in Malaysla
Gradient Method for Finding Optimal Scheduling
in Infinite Dimensional Models of Chemotherapy
JAROSLAW SMIEJA*, ANDRZEJ SWIERNIAK and ZDZISLAW DUDA
Institufe qfiiutomation, Silesian Technical Uni~,ersityAkademicka 16, 44-100 Gliwice,Poland
(ReceivedNovember; 1998; In final form March 20, 2000)
One of the major obstacles against succesful chemotherapy of cancer is the emergence of
resistance of cancer cells to cytotoxic agents. Applying optimal control theory to mathemati-
cal models of cell cycle dynamics can be a very efficient method to understand and, eventu-
ally, overcome this problem. Results that have been hitherto obtained have already helped to
explain some observed phenomena, concerning dynamical properties of cancer populations.
Because of recent progress in understanding the way in which chemotherapy affects cancer
cells, new insights and m
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