Measurement of Photoreceptor Layer in Glaucoma A Spectral-Domain Optical Coherence Tomography Study.pdfVIP

Hindawi Publishing Corporation Journal of Ophthalmology Volume 2011, Article ID 264803, 5 pages doi:10.1155/2011/264803 Clinical Study Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study Ning Fan,1, 2 Nina Huang,2 Dennis Shun Chiu Lam,1 and Christopher Kai-shun Leung1 1 Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong Kong 2 Shenzhen Eye Hospital, Jinan University, Shenzhen 518001, China Correspondence should be addressed to Christopher Kai-shun Leung, cksleung@.hk Received 7 March 2011; Accepted 29 April 2011 Academic Editor: R. N. Weinreb Copyright © 2011 Ning Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To measure and compare photoreceptor layer thickness between normal and glaucomatous eyes using spectral-domain optical coherence tomography (OCT). Methods. Thirty-eight healthy normal volunteers and 47 glaucoma patients were included in the analysis. One eye from each participant was randomly selected for macula imaging by a spectral-domain OCT (3D OCT- 1000, Topcon, Tokyo, Japan). The foveal and parafoveal (1.5 mm from the fovea) outer nuclear layer (ONL) and inner and outer segments (IS+OS) layer thicknesses were measured by a single masked observer. The measurements were repeated 3 times in a random sample of 30 normal eyes to determine the repeatability coefficient and intraclass correlation coefficient. Results. The measurement variabilities of photoreceptor thickness were low. The respective intraclass correlation coefficients of ONL an