Evidence for a cytoplasmic microprocessor of pri-miRNAs.PDFVIP

REPORT Evidence for a cytoplasmic microprocessor of pri-miRNAs JILLIAN S. SHAPIRO, RYAN A. LANGLOIS, ALISSA M. PHAM, and BENJAMIN R. TENOEVER1 Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA ABSTRACT microRNAs (miRNAs) represent a class of noncoding RNAs that fine-tune gene expression through post-transcriptional silencing. While miRNA biogenesis occurs in a stepwise fashion, initiated by the nuclear microprocessor, rare noncanonical miRNAs have also been identified. Here we characterize the molecular components