Human cytomegalovirus pUL37x1-induced calcium flux activates PKCα, inducing altered cell shape and accumulation of cytoplasmic vesicles.PDFVIP

Human cytomegalovirus pUL37x1-induced calcium flux activates PKCα, inducing altered cell shape and accumulation of cytoplasmic vesicles Ronit Sharon-Friling and Thomas Shenk1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544 Contributed by Thomas Shenk, February 11, 2014 (sent for review December 27, 2013) The human cytomegalovirus immediate-early protein pUL37x1 and class III phosphatidylinsoitol 3-kinase (Vps34). Inhibition of induces the release of Ca2+ stores from the endoplasmic reticulum either enzyme not only block