Mature mRNAs accumulated in the nucleus are neither the molecules in transit to the cytoplasm nor constitute a stockpile for gene expression.PDFVIP

RNA (2000) 6962–975 Cambridge University Press Printed in the USA Copyright © 2000 RNA Society Mature mRNAs accumulated in the nucleus are neither the molecules in transit to the cytoplasm nor constitute a stockpile for gene expression DOMINIQUE WEIL, SYLVIE BOUTAIN, AGNÈS AUDIBERT, and FRANÇOIS DAUTRY Institut de Recherche sur le Cancer Centre National de la Recherche Scientifique Unité Propre de Recherche 1983 94801 Villejuif cedex France ABSTRACT In higher eukaryotes, the regulation of pre-mRNA processing is still poorly known. The accumulation of various mature mR