Knockdown of SLBP results in nuclear retention of histone mRNA.PDFVIP

Knockdown of SLBP results in nuclear retention of histone mRNA KELLY D. SULLIVAN,1,3 THOMAS E. MULLEN,1,3 WILLIAM F. MARZLUFF,1,2 and ERIC J. WAGNER1,2 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA 2 Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA ABSTRACT Histone mRNAs are the only eukaryotic cellular mRNAs that are not polyadenylated. Synthesis of mature histone mRNA requires only a single processi