Monoclonal Antibodies to NTF2 Inhibit Nuclear Protein Import by Preventing Nuclear Translocation of the GTPase Ran.PDFVIP

Molecular Biology of the Cell Vol. 11, 703–719, February 2000 Monoclonal Antibodies to NTF2 Inhibit Nuclear Protein Import by Preventing Nuclear Translocation of the GTPase Ran Susanne M. Steggerda, Ben E. Black, and Bryce M. Paschal* Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, and Cell and Molecular Biology Program, University of Virginia Health Sciences Center, Charlottesville, Virginia, 22908 Submitted July 14, 1999; Revised November 2, 1999; Accepted November 30, 1999 Monitoring Editor: Chris Kaiser Nuclear transport factor 2 (NTF2) is a