N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2.PDFVIP

A r t i c l e N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2 Emily B. Pratt, Paul Tewson, Cathrin E. Bruederle, William R. Skach, and Show-Ling Shyng Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239 Functional integrity of pancreatic adenosine triphosphate (ATP)-sensitive potassium (KATP ) channels depends on the interactions between the pore-forming potassium channel subuni