不同金属烤瓷冠对龈沟液血管内皮生长因子水平的影响.docVIP

不同金属烤瓷冠对龈沟液血管内皮生长因子水平的影响 作者：贺小宁，赵燕玲，胡宇平 【摘要】 目的探讨不同金属烤瓷材料对龈沟液血管内皮生长因子(VEGF)水平的影响。方法把采用镍铬合金(T1组)、钛合金(T2组)、钯金合金(T3组)烤瓷冠修复的患者(30颗牙)分为3组，用滤纸条采取修复前和修复后6个月修复牙龈沟液，检测龈沟液量并用酶联免疫吸附法检测 VEGF 的浓度。结果患牙采用金属烤瓷冠修复前，3组龈沟液量的差异无统计学意义(Pgt;0.05)，3组龈沟液VEGF水平无统计学意义(Pgt;0.05)。同修复前相比，修复后T1及T2组龈沟液量和龈沟液中VEGF水平增高均有统计学意义。T3组龈沟液量和龈沟液中VEGF水平修复前后均无统计学意义(Pgt;0.05)。T3组修复后与T1、T2组比较均有统计学意义。结论不同种类金属烤瓷基底材料对牙周组织的刺激程度不同,牙科合金材料对龈沟液血管内皮生长因子水平有影响。 【关键词】 金属烤瓷;牙龈炎;龈沟液;血管内皮生长因子 　[Abstract]ObjectiveTo study the effects of different alloys to the periodontal tissue health.MethodsA total of 30 cases were divided into 3 groups: T1，Ni-Cr alloy;T2 : Ti alloy;T3 : Pd-Au alloy respectively. The gingival cervicular fluid(GCF)of the re-operation and the operative 6-months after therapy were taken by using periopaper to detect the volume of GCF and the concentration of VEGF through ELISA.ResultsBefore the operation，there is no statistical significance in volume(F=2.766，Pgt;0.05)and VEGF level(F=0.250，Pgt;0.05)of the three GCF，but after 6-months the volumes of GCF in group T1,T2 and T3 were (0.718±0.049)μl，(0.648±0.319)μl，( 0.648±0.319)μl and (0.609±0.111)μl; the VEGF levels were (39.856±10.499) pg/ml，(39.893±8.848) pg/ml and ( 22.162±2.972) pg/ml. Compared with the post-operation，the volume of GCE and VEGF in T1 and T2 increased，the significance was only observed in T1 and T2，after operation，compared with T3 the volume of GCF and VEGF in T1 and T2 were significance increased.Conclusion It was concluded Pd-Au alloy is better for periodontal tissue than that of Ti alloy and Ni-Cr alloy，but the long-term effect will be observed. 　　[Key words]Metal ceramic alloys; Gingivaltis; Gingival crevicular fluid; Vascular endothelial growth factor 　　本研究通过对不同金属烤瓷修复冠龈沟液血管内皮生长因子(VEGF)水平进行测量，探讨不同种类金属基底材料行冠修复后，对牙周组织产生的影响，为临床医师选择烤瓷修复体提供指导依据。 　　1资料与方法 　　1.1一般资料： 　　选择2007-2008年我科门诊行烤瓷冠修复患者，要求全身健康，无系统性疾病，如肝炎、糖尿病、心血管疾病和血液性疾病等，口腔卫生状况较好，无牙周炎的患者。研究对象30颗牙，分别采用镍铬合金、钛合金、钯合金烤瓷冠修复各10例，随机分为3组：T1组,选用镍铬合金制作烤瓷修复;T