5-羟色胺转运启动区(5-httlpr)基因多态性与抑郁症患者抉择效用的关系.pdf

IIIIII UllI IIIIIIUIIIIII 义(p0．05)。 4、结论 1)抑郁症患者5-HTTLPR的SS型更易发病，S等位基因可能是其易感基因。 2)抑郁症患者抉择反应时较正常人延长；抑郁症患者倾向于风险回避。 症患者的抉择加工有影响。 研究生：徐圣芬(老年医学) 指导教师：郭宗君主任医师 关键词：抑郁症；五羟色胺转运体启动子区；抉择；转录活性 The the 5-HTTLPRGene about of RelationshipPolymorphism andthe ofDecision inPatientswith Utility making Depression Abstract 1、Objective To the of5-HTTLPR and of utility study relationship genepolymorphism in decision-makingpatients、析mdepression． 2、Methods with measu陀5-HTTLPRandallelesof100 mildor 1)To genotypes patients moderate fromHan 100normalcontrolsPeR depression Chinese，and by toobservethedifferencesbetween andnormal patients amplification，and depression controls． wereexaminedthreedifferentkindsofdecision subjects by tasks(risk、 2)AU and with recordedreactiontime、correct ambiguitycertain)programmedE-prime，and ratesandrisk whether5-HTTLPR andalleleshad appetites，andanalyzed genetypes chioce． on impact 3、Resuits in 1)Therewere differences 5-HTTLPR significant statistically