semantic web for life sciences - world wide web consortium.pptVIP

From Bench to Bedside:Applications to Drug Discovery and Development  Eric Neumann  W3C HCLSIG co-chair Teranode Corporation HCLSIG F2F Cambridge MA Knowledge“--is the human capacity (both potential and actual) to take effective action in varied and uncertain situations.” Drug Innovation and the Technology Gap New Regulatory Issues Confronting Pharmaceuticals Translational Medicine Enable physicians to more effectively translate relevant findings and hypotheses into therapies for human health Support the blending of huge volumes of clinical research and phenotypic data with genomic research data Apply that knowledge to patients and finally make individualized, preventative medicine a reality for diseases that have a genetic basis Role of Informatics John Glaser, CIO Partners Healthcare Providing high quality and efficient health care isnt possible anymore without a sophisticated marriage of information technology and state-of-the-art science. Bringing these together to inform patient care is a tremendous undertaking… the full array of new information provided by genomic research must be harnessed and made real for doctors and patients A Framework for conducting clinical research in and across large multidisciplinary academic medical centers is designed to establish a new biomedicine to fully exploits the fruit of the genomic revolution for clinical practice and allows clinical care to be leveraged to advance basic biological research. Challenges for Drug DD Counteracting the legacy of “Silos” How to break away from the DD “conveyor belt model” to the “Translation model” gaining and sharing insights throughout the process The Benefit of New Targets for New Diseases How to best identify safety and efficacy issues early on, so that cost and failure are reduced A D3 Knowledge-base: Drugability and Safety Drug Discovery Development Knowledge Drug Discovery Development Knowledge Communities and Interoperability Semantic interoperability is directly ti