effects of dietary potassium citrate supplementation on urine.pdfVIP

Effects of dietary potassium citrate supplementation on urine pH and urinary relative supersaturation of calcium oxalate and struvite in healthy dogs Abigail E. Stevenson, BSc; David J. Wrigglesworth, BSc; Brigitte H. E. Smith, BSc; Peter J. Markwell, BSc, BVetMed In humans, oral intake of potassium citrate does Objective—To assess the effect of dietary potassium not directly affect the amount of citrate excreted in the citrate supplementation on the urinary pH, relative urine, because most citrate that is absorbed from the supersaturation of calcium oxalate and struvite 2 (defined as the activity product/solubility product of the gastrointestinal tract is metabolized to bicarbonate. substance), and concentrations of magnesium, ammo- This creates an alkaline tide and a resultant increase in nium, phosphate, citrate, calcium, and oxalate in dogs. urinary excretion of citrate caused by an increase in Animals—12 healthy adult dogs. production of citrate within the mitochondria of renal cells1 or a decrease in tubular reabsorption of citrate in Procedure—Canned dog food was fed to dogs for 37 3 days. Dogs were randomly allocated to 3 groups and the proximal tubular cells. Metabolic alkalosis results fed test diets for a period of 8 days. Study periods in an increase in urine pH and an increase in reabsorp- were separated by 6-day intervals. During each study tion of calcium in the distal tubule.3 As much as 60% period the dogs wer