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Four-Chamber Heart Modeling and Automatic Segmentation for 3D Cardiac CT Volumes a a b∗ Yefeng Zheng , Bogdan Georgescu , Adrian Barbu , c a Michael Scheuering , and Dorin Comaniciu aIntegrated Data Systems Department, Siemens Corporate Research, Princeton, NJ, USA bSchool of Computational Science, Florida State University, USA cSiemens Medical Solutions CTE-PA, D-91301 Forchheim, Germany ABSTRACT Multi-chamber heart segmentation is a prerequisite for quantification of the cardiac function. In this paper, we propose an automatic heart chamber segmentation system. There are two closely related tasks to develop such a system: heart modeling and automatic model fitting to an unseen volume. The heart is a complicated non-rigid organ with four chambers and several major vessel trunks attached. A flexible and accurate model is necessary to capture the heart chamber shape at an appropriate level of details. In our four-chamber surface mesh model, the following two factors are considered and traded-off: 1) accuracy in anatomy and 2) easiness for both annotation and automatic detection. Important landmarks such as valves and cusp points on the interventricular septum are explicitly represented in our model. These landmarks can be detected reliably to guide the automatic model fitting process. We also propose two mechanisms, the rotation-axis based and parallel-slice based resampling methods, to establish mesh point correspondence, which is necessary to build a statistical shape model to enforce priori shape constraints in the model fitt