Journal of Biomedical Informatics.pdfVIP

Journal of Biomedical Informatics 49 (2014) 32–44 Contents lists available at ScienceDirect Journal of Biomedical Informatics journal homepage: www.else /locate/yjbin Robust gene signatures from microarray data using genetic algorithms enriched with biological pathway keywords R.M. Luque-Baena a,⇑, D. Urda a,b, M. Gonzalo Claros c, L. Franco a,b, J.M. Jerez a,b a Departmento de Lenguajes y Ciencias de la Computación, University of Málaga, Bulevar Louis Pasteur, 35, 29071 Málaga, Spain b Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain c Supercomputing and Bioinformatics Centre, University of Málaga, C/ Severo Ochoa, 34, 29590 Málaga, Spain a r t i c l e i n f o a b s t r a c t Article history: Genetic algorithms are widely used in the estimation of expression profiles from microarrays data. How- Received 24 July 2013 ever, these techniques are unable to produce stable and robust solutions suitable to use in clinical and bio- Accepted 16 January 2014 medical studies. This paper presents a novel two-stage evolutionary strategy for gene feature selection Available online 27 January 2014 combining the genetic algorithm with biological information extracted from the KEGG database. A com- parative study is carried out over public data from three different types of cancer (leukemia, lung cancer Keywords: and prostate cancer). Even though the analyses only use features having KEGG information, the results DNA analysis