a pb1 t296r substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic h1n1 influenza virus in mice：一个pb1 t296r替代增强聚合酶活性和赋予一个恶毒的表型2009甲型h1n1流感病毒感染小鼠.pdf

Virology 486 (2015) 180 –186 Contents lists available at ScienceDirect Virology journal homepage: /locate/yviro A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice Zhijun Yu a,b, Kaihui Cheng c, Weiyang Sun b, Xinghai Zhang b, Yuanguo Li b, b b d b b b Tiecheng Wang , Hualei Wang , Qianyi Zhang , Yue Xin , Xue Li , Kun Zhang , b b a e f d Jing Huang , Songtao Yang , Chuan Qin , Peter R. Wilker , Donghui Yue , Hualan Chen , Yuwei Gao b,g,n, Xianzhu Xia a,b,g,h,nn a Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China b Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun 130122, China c Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Jinan 250132, China d State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China e Department of Microbiology, University of Wisconsin-La Crosse, La Crosse, Wisconsin, 54601, USA f Basic Medical College,Changchun University of Traditional Chinese Medicine, Changchun, 130117, China g Jiangsu Co-innovation C