aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia:异常的高频振荡记录在精神分裂症的神经发育模型大鼠methylazoxymethanol醋酸伏隔核.pdf
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aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia:异常的高频振荡记录在精神分裂症的神经发育模型大鼠methylazoxymethanol醋酸伏隔核
Progress in Neuro-Psychopharmacology Biological Psychiatry 61 (2015) 44–51
Contents lists available at ScienceDirect
Progress in Neuro-Psychopharmacology Biological
Psychiatry
journal homepage: /locate/pnp
Aberrant high frequency oscillations recorded in the rat nucleus
accumbens in the methylazoxymethanol acetate neurodevelopmental
model of schizophrenia
Sailaja A. Goda a,⁎, Maciej Olszewski a, Joanna Piasecka a, Karolina Rejniak a, Miles A. Whittington b,
Stefan Kasicki a, Mark J. Hunt a,b
a Laboratory of the Limbic System, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland
b The Hull York Medical School, University of York, Heslington, York YO10 5DD, UK
a r t i c l e i n f o a b s t r a c t
Article history: Background: Altered activity of the nucleus accumbens (NAc) is thought to be a core feature of schizophrenia and
Received 8 January 2015 animal models of the disease. Abnormal high frequency oscillations (HFO) in the rat NAc have been associated
Received in revised form 30 March 2015 with pharmacological models of schizophrenia, in particular the N-methyl-D-aspartate receptor (NMDAR)
Accepted 30 March 2015 hypofunction model. Here, we tested the hypothesis that abnormal HFO are also associated with a
Available online 7 April 2015
neurodevelopmental rat model.
Methods: Using prenatal administration of the mitotoxin methylazoxymethanol ac
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