ability of intermittent androgen suppression to selectively create a non-trivial periodic orbit for a type of prostate cancer patients：间歇性雄激素抑制的能力选择性地创建一个非平凡的周期轨道的一种类型的前列腺癌患者.pdf

Journal of Theoretical Biology 384 (2015) 147 –152 Contents lists available at ScienceDirect Journal of Theoretical Biology journal homepage: /locate/yjtbi Ability of intermittent androgen suppression to selectively create a non-trivial periodic orbit for a type of prostate cancer patients Yoshito Hirata n, Kazuyuki Aihara Institute of Industrial Science, The University of Tokyo, Tokyo, Japan H I G H L I G H T S Examined if a periodic orbit can be targeted in intermittent androgen suppression. A periodic orbit can be targeted only when a patient is classified as type (i). Another strategy must be sought when the relapse of prostate cancer is inevitable. a r t i c l e i n f o a b s t r a c t Article history: Intermittent androgen suppression is becoming a standard clinical option for patients who suffer from Received 7 June 2015 recurrence after an initial treatment of prostate cancer such as radiation therapy and radical Received in revised form prostatectomy. In the first mathematical model of intermittent androgen suppression (Ideta et al., 13 August 2015 2008), the authors tried to control the trajectory of the model to a periodic orbit to enable patients to Accepted 13 August 2015 coexist with prostate cancer, even if it cannot be eradicated. Recently, we proposed a mathematical Available online 28 August 2015 model capable of improving the quantita