2型糖尿病环境因素和DNA甲基化研究分析进展.pdfVIP

HEREDITAS (Beijing) 2013 10 , 35(10): 1143―1152 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2013.01143 2 型糖尿病环境因素与DNA 甲基化的研究进展 1 1,2 1,2 1,2 1,2 3 1,2 汤琳琳 , 刘琼 , 步世忠 , 徐雷艇 , 王钦文 , 麦一峰 , 段世伟 1. , , 315211; 2. , , 315211; 3. , 315000 2 型糖尿病(Type 2 diabetes mellitus, T2DM)是由于遗传与环境因素共同作用而引起葡萄糖代谢紊乱的疾 病。DNA 甲基化修饰的研究发现环境因素可以通过影响DNA 甲基化修饰, 显著地增加T2DM 的患病风险。目 前, T2DM 环境相关基因的DNA 甲基化修饰研究已在人及动物的不同组织中取得进展。此外, T2DM 相关基因 的甲基化研究主要集中在糖代谢、能量代谢、炎症等。文章系统地综述了目前T2DM 致病环境因素与DNA 甲 基化研究进展。 2 型糖尿病(T2DM); 表观遗传学; DNA 甲基化; 环境因素 The effect of environmental factors and DNA methylation on type 2 diabetes mellitus 1 1,2 1,2 1,2 1,2 TANG Lin-Lin , LIU Qiong , BU Shi-Zhong , XU Lei-Ting , WANG Qin-Wen , 3 1,2 MAI Yi-Feng , DUAN Shi-Wei 1. Zhejiang Provincial Key Laboratory of Pathophysiology , School of Medicine, Ningbo University, Ningbo 315211, China; 2. Diabetes Center, Ningbo University, Ningbo 315211, China; 3. The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo 315000, China Abstract: Type 2 diabetes mellitus (T2DM) is a glucose metabolic disorder driven by both genetic and environmental factors. Recent DNA methylation studies have established that T2DM may be contributed by environmental factors through the regulation of DNA methylation. Human and animal model studies have made much progress on the interaction between DNA methylation of T2DM genes and environmental factors in multiple tissues. Current studies on DNA methylation of T2DM genes mainly focus on glucose and energy metabolism, inflammati