Pax基因家族在果蝇发育过程中的调控作用.pdfVIP

HEREDITAS (Beijing) 2010 2 , 32(2): 115―121 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2010.00115 Pax 基因家族在果蝇发育过程中的调控作用 李莉, 杨杨, 薛雷 , 200092 Pax 是一个在进化上相当保守的基因家族, 它们编码的产物是一组极为重要的转录调控因子, 并存在于 从果蝇到人类的各种生物体中, 参与细胞内信号传导通路的调控, 在胚胎发育过程中对细胞分化、更新、凋亡 起重要的调控作用, 影响器官和组织的形成。果蝇中已发现 10 个Pax 基因家族成员, 它们对果蝇胚胎发育及成 虫组织器官的分化有非常重要的调控作用。文章结合最新的研究进展, 就果蝇中Pax 基因的结构、表达模式和 主要功能做一简要综述。 Pax 基因; 转录因子; 果蝇; 发育 Regulatory functions of Pax gene family in Drosophila development LI Li, YANG Yang, XUE Lei School of Life Science and Technology, Tongji University, Shanghai 200092, China Abstract: The Pax gene family encodes a group of important transcription factors that have been evolutionary conserved from Drosophila to human. Pax genes play pivotal roles in regulating diverse signal transduction pathways and organo- genesis during embryonic development through modulating cell proliferation and self-renewal, embryonic precursor cell migration, and the coordination of specific differentiation programs. Ten members of the Pax gene family, which perform crucial regulatory functions during embryonic and postembryonic development, have been identified in Drosophila . In this report, we described the protein structures, expression patterns, and main functions of Drosophila Pax genes. Keywords: Pax genes; transcription factors; Drosophila ; development Pax , RED=PAIRED) , PAIDNA, ; REDDNA, [2] , Pax , 9 Pax(Pax1-Pax9) paired (prd ) gooseberry (gsb)[1], , Pax (Paired box)PaxPax