乳腺癌中p27p53表达的临床意义及相互关系.pdfVIP

中 文 摘 要 目的探讨p27和p53蛋白表达在乳腺癌中的作用及其相互关系。方法收集63 例乳腺癌及38例乳腺纤维腺瘤手术标本，采用免疫组化S—P法检测p27及p53蛋白在 各例中的表达情况。结果 (1)p27蛋白在乳腺癌组织和乳腺纤维腺瘤中表达的阳性 率分别为65．08％和84．21％o027蛋白在乳腺癌组织中表达与其在乳腺纤维腺瘤中表 阳性率分别为55．56％和18．42％。p53蛋白在乳腺癌组织中表达与其在乳腺纤维腺瘤 (4)p27蛋白与p53蛋白表达呈负相关(r=-0．253 与乳腺癌发生、发展及腋淋巴结转移有关，p27和p53蛋白的表达呈负相关，p27和p53 蛋白的表达对判断乳腺癌临床进展有一定的参考价值。 关键词乳腺癌免疫组织化学p27蛋白p53蛋白 Clinical andcorrelationof and significance p27 inbreastcarcinoma p53expression Abstract To clinical andcorrelationof and Objectiveexplorer significance p27 p53expression carcinoma．MethodsCollectionof63casesofbreastcarcinomaand38casesofbreast breast fibroadenoma．CollectedimmunohistochemicalS—Pmethoddetectedfor and p27 p53protein Was inthecaseofthe rateof 65．08％in expression．Results(1)PositiveexpressionpZ7 breastcarcinomaand84．21％inbreast differencewas fibroadenoma(PO．05)，thesignifi- of Was55．56％inbreastcarcinomaand18．42％in rate cant．(2)Positive p53 expression breast differenceWas and were fibroadenoma(P0．05)，thesignificant．(3)Bothp27 p53 notcorrelatedwith of of werecorrelated tumor，the PR(PO．05)，they age，sizes expression be- withthe nodemetastasisand correlationexisted lymph ER(PO．05)．(4)Thenegative tweenthe of and