癫痫的治疗资料.ppt

生物利用度 是指经过肝脏首过消除过程后，能被吸收进入机体体循环的药物相对量和速度。与药物的理化性质、剂型、给药途径及机体状态有关 * 药物消除速度是大多数AEDs作用时间的决定因素 * Anticonvulsants target ion channels and neurotransmitters that mediate the balance between neuronal excitation and inhibition1 Scharfman HE. The neurobiology of epilepsy. Curr Neurol Neurosci Rep. 2007;7:384-354. References for Chart [drug]: Rogawski MA, Bazil CW. New molecular targets for antiepileptic drugs: α2δ, SV2A, and Kv7/KCNQ/M potassium channels. Curr Neurol Neurosci Rep. 2008;8:345-352. [retigabine; brivaracetam] Rogawski MA. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 2006;69:273-294. [eslicarbazine; rufinamide] Rogawski MA, L?scher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004;5:553-564. [vigabatrin; carbamazepine; benzodiazepines; phenytoin; phenobarbital] Liu Y, Yohrling GJ, Wang Y, et al. Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons. Eilepsy Res. 2009;83:66-72. [carisbamate] Vimpat? Prescribing Information. Smyrna, GA: UCB, Inc.; 2008. [lacosamide] Lyrica ? Prescribing Information. New York, NY: Pfizer, Inc.; 2007. [pregabalin] Zonegran ? Presecribing Information. Teaneck, NJ: Eisai Inc.; 2006. [zonisamide] Trileptal ? Prescribing Information. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2009. [oxcarbaxepine] Keppra ? Prescribing Information. Smyrna, GA: UCB, Inc.; 2009 [levetiracetam] Gabatril ? Prescribing Information. Frazer, PA: Cephalon, Inc.; 2009 [tiagabine] Topamax ? Prescribing Information. Raritan, NJ: Ortho-McNeil Pharmaceutical, Inc; 2005 [topiramate] Lamictal ? Prescribing Information. Research Triangle Park, NC: GlaxoSmithKline; 2007 [lamotrigine] Neurontin ? Prescribing Information. New York, NY: Pfizer, Inc.; 2005 [gabapentin] Felbatol ? Prescribing Information. Somerset, NJ: MedPointe Pharmaceuticals; 2002 [felbamate] Depakote ? Prescribing Information. North Chicago, IL: Ab