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田七注射液对阿素肾纤维化大鼠的hgf及tgf-β1smads信号通路的影响
目 录
中英文缩略词表 ···············································1
中文摘要·····················································3
英文摘要 ·····················································5
引 言 ·····················································8
正 文 ····················································10
1 实验材料和方法 ············································10
1.1 实验材料 ·················································10
1.2 实验方法 ·················································11
2 实验结果 ··················································17
2.1 一般情况 ·················································17
2.2 各组大鼠死亡情况 ·········································18
2.3 各组大鼠肾组织肉眼观察···································19
2.4 各组大鼠尿蛋白的比较·····································20
2.5 各组大鼠Cr 和BUN 的比较·································20
2.6 各组大鼠肾组织病理改变···································2 1
2.7 各组大鼠肾组织免疫组化的比较 ·····························22
3 讨 论 ···················································23
3.1 祖国医学对肾纤维化概念的认识 ·····························23
3.2. 中医学对肾纤维化病因病机的认识···························25
3.3 中医学对治疗肾纤维化的认识·······························25
3.4 单味中药抗肾纤维化机制的研究·····························26
3.5 三七抗肾纤维化作用的研究·································29
3.6 肾纤维化形成的机制·······································30
3.7 TGF-β /Smads 信号传导通道与肾纤维化关系···················32
1
3.8 肝细胞生长因子与肾纤维化关系·····························35
1
4 存在的问题和展望 ··········································37
结 论 ····················································38
参考文献 ····················································39
附 录 ····················································45
综 述 ····················································48
致 谢 ····················································55
攻读学位期间发表的学术论文目录 ······························56
作者声明 ···················································
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